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Post by seawell on Apr 7, 2020 10:58:43 GMT -6
Just a side note in regards to the super important medical side of things vs. the economic realities we are absolutely facing now. A friend of mine went to his cancer doctor last Friday. His doctor has been treating Covid-19 patients (I don't know how many). This doc is FAR more more concerned about the economic factors than the disease. The reason being? Every patient he has treated has recovered or is in process of recovering, and he sees little "fatality" danger from C-19 unless 1.) you are high risk or 2.) have pre-existing conditions that make you more susceptible or 3.) you wait too long for treatment - or worse case, all 3. I'm not sure why we don't hear more about this. Not sure if it's right or wrong, but in case anyone here gets or has a loved one who gets C-19, here's what's working for this doc - and hs patients. - His #1 warning - catch it early, and go into treatment BEFORE you get the test results. He says there is minimal downside aside from a few pre-existing conditions, but it's his belief that the reason people are dying is that they are waiting too long to get the test results, then they are really sick, then....boom. This disease acts fast - if it looks like you have it, act quickly and get treatment ASAP. Here's this docs prescription : - Intravenous mega-dose of Vitamin C given immediately at the office. - Hydroxychloroquine Treatment - Z-Pack Treatment - Zinc Oxide Pills - In addition, before any of this happens, if you are at high risk, self quarantine yourself for a few months until a vaccine and other treatments are available. I don't know much more than that, but that's his basic treatment - for what it's worth. Why are we not hearing these success stories? Even if anecdotal... Thanks for sharing this! One of the hardest parts of dealing with my friend that passed away is that the way his case went was pretty much the opposite of what your doctor is recommending. His doctor advised him to stay home way too long(10 days with a fever before going to the hospital) didn't test until it was too late and didn't try any of the therapeutic interventions until it was way too late. Knowing what we know now, I'd definitely demand testing and treatment early if you have any inkling that you may have it.
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Post by drbill on Apr 7, 2020 11:05:33 GMT -6
Just a side note in regards to the super important medical side of things vs. the economic realities we are absolutely facing now. A friend of mine went to his cancer doctor last Friday. His doctor has been treating Covid-19 patients (I don't know how many). This doc is FAR more more concerned about the economic factors than the disease. The reason being? Every patient he has treated has recovered or is in process of recovering, and he sees little "fatality" danger from C-19 unless 1.) you are high risk or 2.) have pre-existing conditions that make you more susceptible or 3.) you wait too long for treatment - or worse case, all 3. I'm not sure why we don't hear more about this. Not sure if it's right or wrong, but in case anyone here gets or has a loved one who gets C-19, here's what's working for this doc - and hs patients. - His #1 warning - catch it early, and go into treatment BEFORE you get the test results. He says there is minimal downside aside from a few pre-existing conditions, but it's his belief that the reason people are dying is that they are waiting too long to get the test results, then they are really sick, then....boom. This disease acts fast - if it looks like you have it, act quickly and get treatment ASAP. Here's this docs prescription : - Intravenous mega-dose of Vitamin C given immediately at the office. - Hydroxychloroquine Treatment - Z-Pack Treatment - Zinc Oxide Pills - In addition, before any of this happens, if you are at high risk, self quarantine yourself for a few months until a vaccine and other treatments are available. I don't know much more than that, but that's his basic treatment - for what it's worth. Why are we not hearing these success stories? Even if anecdotal... Thanks for sharing this! One of the hardest parts of dealing with my friend that passed away is that the way his case went was pretty much the opposite of what your doctor is recommending. His doctor advised him to stay home way too long(10 days with a fever before going to the hospital) didn't test until it was too late and didn't try any of the therapeutic interventions until it was way too late. Knowing what we know now, I'd definitely demand testing and treatment early if you have any inkling that you may have it. So sorry about your friend Seawell. So sorry. Yeah, that sure seems to be bad advice. And it's essentially the advice that my brother in law's hospital is giving out. They are not testing unless you are BAD, and they send you home and say to come back if you need hospitalization. Then you get tested. They are not that busy at the hospital, but they don't have the testing resources - and even when tested, it takes a week or so to get the results. And honestly, but the time you get tested, find out you're positive, and start with some treatment, you are already in bad shape - which is why I think we're seeing such a high death toll. Get the damn treatment and find out LATER if you're sick. Take the above doctors advice. The potential downside to starting treatment early is far less risky than waiting it out and hoping for the best. Again, condolences for your friend and his family.
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Post by matt@IAA on Apr 7, 2020 12:28:38 GMT -6
The reason is because those are basically guesses at treatment, and may or may not be any different than sugar pills or any other placebo. Vitamin C was a test in China, not replicated. Hydroxychloroquine is all the rage right now, and there are about 60 ongoing studies between HCL and Chloroquine. Two of the early ones showed no benefit vs control, one showed minor benefit (faster clearing of chest CT on 30 patient study).
Remember 99% of people are going to get better without treatment anyway, and if you look at people below 50 it's closer to 999/1000. So you need very large studies to determine the effectiveness of a drug for a disease like this.
The other thing is that HCL can cause heart issues, QT prolongation. It's been observed already for covid19 patients, which is troublesome because covid19 has shown to have direct viral infection of heart tissue... so when people are already on medication that may give heart risk, blanket prescription of HCL may exacerbate this. We don't understand why covid19 seems to affect some people's hearts and others. A guy from my university got it with classic symptoms, and his partner got super mild respiratory symptoms but ended up in the ER for heart arrhythmia from covid19. Thank God his doctor hadn't prescribed him HCL, or he might be dead. Another doc on my university forum has a pt at his hospital who was relatively young, got prescribed HCL, and had an adverse reaction and is now in liver failure. Yes, these are *rare* side effects. But that kid was going to recover...he traded his liver and now needs a transplant for maybe shortening his covid19 illness by a few days.
There is a real ethical/informed consent risk at play here. To get informed consent the patient needs to know clearly the upside AND downside of treatment. Here no doctor can accurately testify to upside, except to say, might help, might not. Fortunately the downside is well known and risks are very low probability.
I don't think politicians should get involved in the prescribing of drugs. That's between patients and doctors. But the publicity surrounding HCL after President Trump's response - and I absolutely do NOT lay this at his feet..plenty of stupidity on both sides between the breathless rebuttal by the left and the doubling down by the right - has resulted in a situation where we are prescribing a drug with no proven benefit for this disease due to groupthink. And, insanely, the average person's opinion about this treatment flows down party lines. That's idiocy.
There are a lot of drug treatments going on right now, for HCL and others. We'll know soon if it works or not.
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Post by drbill on Apr 7, 2020 12:38:48 GMT -6
Hey matt@IAA - you might know the answer to this question : We know that C-19 is being transferred by a lot of asymptomatic people who are infected but don't show symptoms. Is that also true of the standard flu strains? Just curiosity here....
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Post by christopher on Apr 7, 2020 12:52:37 GMT -6
A lot of medical treatments are often not understood, they just try them and sometimes the patient gets better, sometimes they don't work so they try something else. Its a lot of fuzzy math in that world, and there's no perfect explanation like physics can provide. As the decades go by the sample size numbers can get better and better and more studies produce more numbers they can be more sure they understand. That's why I like that Singing Whale cartoon, its awesome how they show the scientists argue over what the truth is..the newpapers go along wth it... until finally the genius scientist comes up with the best explanation and its accepted by all the newspapers. Of course its not the truth.
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Post by matt@IAA on Apr 7, 2020 12:53:42 GMT -6
Want to know something annoying? We don’t really know. I tried to find an answer to this and after reading a bunch of studies it’s not clear. It’s not even well known how much of flus transmission is from aerosols vs droplets, or what percentage people are asymtpomatic carriers. I found studies ranging from 10-50% with a median around 16%. It may vary a lot year to year.
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Post by chessparov on Apr 7, 2020 13:14:10 GMT -6
But Hannity rhymes with Sanity. Sorry couldn't resist. Wait! Maybe this could be the Title...Of an upcoming Rap/Hip Hop collaborative with John Eppstein as the "Dope" (that means smart John E) MC! (I want first db's-ahem-dibs on that name BTW) This might be a way to connect and have Face/Hammer Time with all our "Stay At Homies" Kidding aside, regardless of our individual beliefs... "God bless us, everyone"-Tiny Tim. My favorite line, of my favorite book, by my fave author of all. (even over Shakespeare or Sheldon-Sidney that is!) Whether in our lives, or on a thread like this... Let's all STAY friends, including when I'm right and your obviously wrong! Chris P.S. I'll catch up this thread, before bed tonight. Lots to think about, as I read each post.
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Post by drbill on Apr 7, 2020 13:35:11 GMT -6
Want to know something annoying? We don’t really know. I tried to find an answer to this and after reading a bunch of studies it’s not clear. It’s not even well known how much of flus transmission is from aerosols vs droplets, or what percentage people are asymtpomatic carriers. I found studies ranging from 10-50% with a median around 16%. It may vary a lot year to year. Thanks! Just wondering about the future - when the herd immunity builds up, and we've got vaccines and better, more tested treatments available. Will C-19 just become "another bug" in the everlasting "flu strains" that we deal with every year.... Time will tell....
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Post by matt@IAA on Apr 7, 2020 14:04:45 GMT -6
Covid19 has an rna proofreading function that influenza viruses do not. Means it should be more stable -> better candidate for long term vaccine.
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Post by chessparov on Apr 7, 2020 14:05:11 GMT -6
I doubt it'll last, because it was made in China. IMHO it'll "come back" next year, due to the fact many won't come down with it this year. And then to a much lesser degree, also (generally) each country/area will be much better prepared. Excuse the analogy, but supposedly Robert McNamara almost fainted after the Cuban Missile Crisis... When some critical details, regarding the situation were finally revealed to him. Approximately 20-25% generic chance that we were getting into WWIII with the Russians for one thing. Plus Russian Vice Admiral, Vasily Arkhipov, second-in command of the B-59 submarine... decided to NOT deploy the "Special Weapon" against the US. Please excuse the history lesson, but imagine the outcome of THAT scenario. Enough to scare Archie Bunker! Chris
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Post by Johnkenn on Apr 7, 2020 16:45:39 GMT -6
Regardless where you stand, this shit is funny.
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Post by donr on Apr 8, 2020 0:23:05 GMT -6
The reason is because those are basically guesses at treatment, and may or may not be any different than sugar pills or any other placebo. Vitamin C was a test in China, not replicated. Hydroxychloroquine is all the rage right now, and there are about 60 ongoing studies between HCL and Chloroquine. Two of the early ones showed no benefit vs control, one showed minor benefit (faster clearing of chest CT on 30 patient study). Remember 99% of people are going to get better without treatment anyway, and if you look at people below 50 it's closer to 999/1000. So you need very large studies to determine the effectiveness of a drug for a disease like this. The other thing is that HCL can cause heart issues, QT prolongation. It's been observed already for covid19 patients, which is troublesome because covid19 has shown to have direct viral infection of heart tissue... so when people are already on medication that may give heart risk, blanket prescription of HCL may exacerbate this. We don't understand why covid19 seems to affect some people's hearts and others. A guy from my university got it with classic symptoms, and his partner got super mild respiratory symptoms but ended up in the ER for heart arrhythmia from covid19. Thank God his doctor hadn't prescribed him HCL, or he might be dead. Another doc on my university forum has a pt at his hospital who was relatively young, got prescribed HCL, and had an adverse reaction and is now in liver failure. Yes, these are *rare* side effects. But that kid was going to recover...he traded his liver and now needs a transplant for maybe shortening his covid19 illness by a few days. There is a real ethical/informed consent risk at play here. To get informed consent the patient needs to know clearly the upside AND downside of treatment. Here no doctor can accurately testify to upside, except to say, might help, might not. Fortunately the downside is well known and risks are very low probability. I don't think politicians should get involved in the prescribing of drugs. That's between patients and doctors. But the publicity surrounding HCL after President Trump's response - and I absolutely do NOT lay this at his feet..plenty of stupidity on both sides between the breathless rebuttal by the left and the doubling down by the right - has resulted in a situation where we are prescribing a drug with no proven benefit for this disease due to groupthink. And, insanely, the average person's opinion about this treatment flows down party lines. That's idiocy. There are a lot of drug treatments going on right now, for HCL and others. We'll know soon if it works or not. A doctor still has to prescribe HCQ, so a politician actually has nothing to do with the administration of HCQ to a Corona patient, other than advertising its possible benefit, no? And the politicization of this epidemic is just shameful. If I were sick and getting sicker, I'd probably want to give it a shot. If I was healthy, OTOH, I wouldn't be drinking fish tank cleaner for prophylaxis. I'd imagine anyone sick enough to be hospitalized would be monitored for QT prolongation arrhythmias. I bet a lot of docs have a stash of this for them and theirs. And zinc. I haven't yet read the body of this thread, so pardon me if I just barged in here.
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Post by matt@IAA on Apr 8, 2020 8:12:25 GMT -6
Agreed on all points, including doctors having a stash. Lots of doctors began prescribing to themselves and family so they’d have it on hand, which is a pretty crappy selfish thing to do. Some patients who take it regularly couldn’t get prescriptions filled because of the run - I have a family member in that situation.
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Post by the other mark williams on Apr 8, 2020 8:40:02 GMT -6
Some patients who take it regularly couldn’t get prescriptions filled because of the run - I have a family member in that situation. i have a good friend with lupus, and the run on HCQ is a bit scary for her right now.
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Post by Johnkenn on Apr 8, 2020 8:43:21 GMT -6
Some patients who take it regularly couldn’t get prescriptions filled because of the run - I have a family member in that situation. i have a good friend with lupus, and the run on HCQ is a bit scary for her right now. Was just listening to a podcast where they were talking about some study of thousands of Lupus patients - and not one had contracted Covid. Of course, Lupus patients take Hydroxychloriquine.
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Post by Johnkenn on Apr 8, 2020 8:43:58 GMT -6
IMHE has changed their projection to 60k deaths.
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Post by the other mark williams on Apr 8, 2020 9:00:22 GMT -6
IMHE has changed their projection to 60k deaths. this would be fantastic news! And of course, as I mentioned earlier, there’s no way to know for sure what those numbers would look like *without* social distancing. Just too many variables. I’m someone who generally thinks the public health officials have known what they’re doing with their recommendations, so that’s my own angle on this. I do think the economy will bounce back on the other side of this, though of course I understand not everyone’s business will have survived. To me, that’s one of the main needs of economic stimulus plans: how do we get as many businesses and individuals and families through this as possible. I know it’s all highly imperfect.
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Post by Johnkenn on Apr 8, 2020 10:18:28 GMT -6
IMHE has changed their projection to 60k deaths. this would be fantastic news! And of course, as I mentioned earlier, there’s no way to know for sure what those numbers would look like *without* social distancing. Just too many variables. I’m someone who generally thinks the public health officials have known what they’re doing with their recommendations, so that’s my own angle on this. I do think the economy will bounce back on the other side of this, though of course I understand not everyone’s business will have survived. To me, that’s one of the main needs of economic stimulus plans: how do we get as many businesses and individuals and families through this as possible. I know it’s all highly imperfect. Yeah - I think social distancing has definitely changed things for the better.
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Post by matt on Apr 8, 2020 11:05:49 GMT -6
Here is the full chart: The flatness of the curve suggests that the authors refuse to speculate on the future. If so, it's a wise decision. "Only" 60 thousand dead. More than died in Vietnam, and we built a memorial for that sacrifice. Who will speak for the 10/20/30/60/100/500 thousand dead this time? No one, I'm afraid- the world, in it's eternally fractured political and social discourse, will be too busy blaming each other to remember and appropriately honor the involuntary sacrifice of so many. I hope I'm wrong, but it's already happening. Has been happening- and will surely continue. Franklin Graham is correct: the world is fallen. The proof is not in the virus itself, but in how all too many governments and leaders -and the media- have responded. When no one is responsible, everyone is responsible. We are all in it, up to our necks. Too bad so many people fail to understand this truth, which should be self-evident. Be safe out there!
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Post by drbill on Apr 8, 2020 11:38:29 GMT -6
OK. It's been two weeks and a day since it was predicted right here that "it will be hell on earth in almost every hospital on the planet". And that no one - inferring most of us - understood "exponential". I'm not going to research out everywhere in the world, but I am interested about what's going on where I live.....
So, here's the FACTS in my county as of this morning. It's fairly large, fairly rural, 230k residents, with close proximity to one of the Nations largest cities :
Tested : 1289 Confirmed Positive : 60 Hospitalizations (between TWO decent sized hospitals) : 4. 3 in one, and 1 in the other Deaths : 1
Interestingly, in terms of positive test results, the Adults 18-64 lead the Seniors by double - in a county that is pretty skewed towards seniors.
So, 4 patients in two facilities, close to 300 staffed beds - there's virtually no one in the hospital for any elected surgeries or anything else that they don't HAVE to be there for. Not exactly hell on earth for the staff, although I'm sure for the 4 that are fighting, it's hell on earth for them, and my prayers and best wishes are for a speedy recovery. We are not yet seeing "exponential" growth. It's steady, it's rising, but it's not defining "exponential". At least not yet.
Last week's growth has been : 44, 46, 50, 57, 58, 60, 60. I'm not a mathmatician, but I don't think that is showing exponential, although some math wizard can correct me if I'm wrong.
Maybe, just maybe we can stop with the overinflated hyperbole about the end of life as we know it? Whatever we are doing seems to be having a positive affect. The rest of the country jumped on board way before NYC, and we will not have as brutal a time of it as they have.
PS - my brother-in-law's hospital which is smaller in the Denver area is similar. Cases growing, hospitalizations growing, overall capacity being used is way under normal cause no one wants to be there, and all elective procedures are cancelled.
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Post by svart on Apr 8, 2020 12:07:18 GMT -6
OK. It's been two weeks and a day since it was predicted right here that "it will be hell on earth in almost every hospital on the planet". And that no one - inferring most of us - understood "exponential". I'm not going to research out everywhere in the world, but I am interested about what's going on where I live.....So, here's the FACTS in my county as of this morning. It's fairly large, fairly rural, 230k residents, with close proximity to one of the Nations largest cities : Tested : 1289 Confirmed Positive : 60 Hospitalizations (between TWO decent sized hospitals) : 4. 3 in one, and 1 in the other Deaths : 1 Interestingly, in terms of positive test results, the Adults 18-64 lead the Seniors by double - in a county that is pretty skewed towards seniors. So, 4 patients in two facilities, close to 300 staffed beds - there's virtually no one in the hospital for any elected surgeries or anything else that they don't HAVE to be there for. Not exactly hell on earth for the staff, although I'm sure for the 4 that are fighting, it's hell on earth for them, and my prayers and best wishes are for a speedy recovery. We are not yet seeing "exponential" growth. It's steady, it's rising, but it's not defining "exponential". At least not yet. Last week's growth has been : 44, 46, 50, 57, 58, 60, 60. I'm not a mathmatician, but I don't think that is showing exponential, although some math wizard can correct me if I'm wrong. Maybe, just maybe we can stop with the overinflated hyperbole about the end of life as we know it? Whatever we are doing seems to be having a positive affect. The rest of the country jumped on board way before NYC, and we will not have as brutal a time of it as they have. PS - my brother-in-law's hospital which is smaller in the Denver area is similar. Cases growing, hospitalizations growing, overall capacity being used is way under normal cause no one wants to be there, and all elective procedures are cancelled. The problem is that pointing out the flawed proselytizing of imminent "exponential" death by everyone from learned scholars to those parroting headlines on FB for virtue signalling is that attribution for the flattening will always circle back to social distancing. Even in the data where people were left to die without medical help, the curve flattened on it's own, signifying that there was/is a natural number of deaths that would have happened, but as I stated before, there can be no way to tell a statistical difference between a working quarantine and a gross overreaction. The human inclination is to believe their actions "work" even with very little evidence to the contrary. Of course, governments will cry victory and rhetoric will be at all time highs, academics will continue to believe in their infallibility despite needing to continuously revise their alarmist data down and down and down, and the public at large will shrug and say "oh well, at least we survived" and the outcome will be that nobody will be held responsible for wrecking the economy. There's plenty of 3rd party video available showing a complete lack of "overrun hospitals" in large urban centers. Locally, the news claimed our largest hospital to be "overrun" 2 weeks ago but speaking with a person who works there, it is NOT overrun, but there was a surge of people who were "sick" but since then a lot of them have tested negative. Most surges like this seem to be people convinced by media headlines that they will die if not treated quickly, so they rush to the doctor/hospital at the slightest symptom. I personally know a few people who have been to the doctor multiple times with "symptoms" who have been determined to NOT have nCOV-19 infections. It's pure lunacy to allow this kind of thing to drive us all wild. It's going to be pure insanity to allow those responsible for destroying so many lives to get away with it too.
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Post by chessparov on Apr 8, 2020 12:41:03 GMT -6
Of course Mark's last post is meant in a "relative sense". All of us here, feel bad about all the lives lost, and those who are friends/family with them. Chris
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Post by matt@IAA on Apr 8, 2020 12:44:20 GMT -6
Two guys go for a walk, and pass by a burning house. The first says - "Oh no! That house is going to burn down!" and calls 911. They watch thoughtfully as the fire department shows up and puts out the fire. As they walk away, the second looks at the first and finally speaks up, saying "boy...you sure don't know much about fires."
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Post by drbill on Apr 8, 2020 13:11:46 GMT -6
Two guys go for a walk, and pass by a burning house. The first says - "Oh no! That house is going to burn down!" and calls 911. They watch thoughtfully as the fire department shows up and puts out the fire. As they walk away, the second looks at the first and finally speaks up, saying "boy...you sure don't know much about fires." You know - that sounds pretty disingenuous to me. There's a difference between saying "hey call 911 - the house is burning down" (that's the right thing to do) and saying "hey that house is burning down - call 911 cause the entire block is gonna go, then the city, and the government is going to go bankrupt and won't be able to deal with the issues, and all of humanity is on the brink of collapse." - that's not responsible, and not the right thing to do. And demanding that everyone do the latter? Crazytalk. Pardon, my fairly over the top example, but we are not that far from it in various media venues.
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Post by the other mark williams on Apr 8, 2020 13:13:23 GMT -6
Of course Mark's last post is meant in a "relative sense". All of us here, feel bad about all the lives lost, and those who are friends/family with them. Chris Yes yes - thank you for pointing that out, Chris! By no means do I think it's fantastic that there is loss of life, of course. Only that there may be less than had we done nothing.
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