Post by [email protected] on Apr 13, 2021 11:20:37 GMT -6
It's been a mixed bag, all kinds of things have been proposed. But the thing is, it's not on the onus of the clinical trial to disprove the theory. The burden of proof is the other way around. We basically assume that things don't work until they can be shown to be effective, from a clinical point of view. The null hypothesis is that the drug doesn't work.
There hasn't been a single study that validates or supports the claim that hydroxychloroquine with this or that or not or whatever actually does anything for people with COVID19. It does some things in vitro, we know that. Zinc does stuff in high enough concentrations. It may be a zinc ionophore, whatever. The problem is a known method of action in one way doesn't necessarily mean the thing will work like that in treatment.
And the truth is the evidence has actually been to the contrary. Not only does hydroxychloroquine as a treatment not appear to work in clinical studies, the largest studies we've seen is that it appears to be actively harmful. In the largest randomized study I know of (NEJM) with patients receiving hydroxychloroquine were less likely to be discharged alive within 28 days and more likely to be ventilated or die. And this excluded people with QT prolongation from the study, which is probably a bigger risk that sits on top if you're talking about mass treatment.
What is incredible to me is that the list of failed therapeutics for COVID is long and distinguished. There's no particular conspiracy against hydroxychloroquine - it just got a TON of publicity because the POTUS brought it up, and he is a polarizing figure. If anything it got more than its fair share of funding and chances to prove out because of that publicity. Tons of drugs don't work. Most that have been tried have been shown to be completely ineffective. No doctor wants the drugs to not work, any of them. We really collectively as a society are suffering because of the politicization of... everything.